The moral philosopher Onora O’Neill (Baroness O’Neill of Bengarve) has a longstanding fascination with trustworthiness. She has explored these ideas extensively, through writing and broadcasting (including her 2002 BBC Reith Lectures). Her 2022 book A Philosopher Looks at Digital Communication examines the impact of contemporary forms of communication, including social media. In this conversation we examine issues around trustworthiness within the medical realm and beyond.